Frequently Asked Questions
How does RELiZORB connect to my feeding tube?
RELiZORB is easy to use. It quickly connects in-line directly to your patient’s feeding tube. RELiZORB attaches after the tube feeding pump connector and before connection to the patient. Learn more about how to use RELiZORB here.
Learn more in the RELiZORB Instructions for Use.
What is RELiZORB?
RELiZORB is a digestive enzyme cartridge that contains the enzyme lipase. RELiZORB is used with enteral nutrition to help break down the fats in enteral formula. Lipase is an enyzme that is normally made in the body to break down (digest) fats (triglycerides) into an absorbable form (fatty acids and monoglycerides). The lipase enzyme used in RELiZORB is attached to the white beads (iLipase), which are visible through the side of the cartridge.
What does RELiZORB do?
Properly breaking down (digesting) and absorbing fats is important for normal growth and development. RELiZORB contains a digestive enzyme called lipase that breaks down fats in enteral tube feeding formula into an absorbable form as the formula passes through the RELiZORB cartridge.
How will RELiZORB help with your patient’s enteral tube feedings?
Your patient may have trouble digesting the fats in enteral formula. In clinical studies1,2, RELiZORB was shown to increase the amount of fat that the body absorbs from enteral tube feeding formulas, particularly omega-3 fats.
Why doesn’t tube feeding formula contain absorbable fats?
Fats that are broken down into their absorbable form are not stable and spoil quickly. Therefore, enteral tube feeding formulas are made with fat in triglyceride form, which does not spoil as quickly but also is not absorbable by the body. RELiZORB breaks down the fats into absorbable forms (fatty acids and monoglycerides) during enteral tube feeding.
What pumps can be used with RELiZORB?
RELiZORB must be used with enteral tube feeding pumps that have low flow/no flow alarms. RELiZORB has not been tested for use with gravity feed systems (systems that have no pumps). A detailed listing of pumps, enteral feeding pump tubing sets and patient extension sets tested with RELiZORB can be found here.
What formulas may be used with RELiZORB?
RELiZORB was tested in a laboratory with different enteral tube feeding formulas1. During laboratory testing, RELiZORB was able to break down more than 90% of the fats into their absorbable forms for most of the formulas tested. These tests were done with 500 mL of formula with an enteral tube feeding pump set at a high flow rate of 120 mL/hour. The same or better fat breakdown was shown when RELiZORB was used with volumes lower than 500 mL and flow rates as low as 24 mL/hour. A detailed listing of formulas tested with RELiZORB can be found here.
How much formula can each RELiZORB be used for?
Each RELiZORB cartridge may be used for up to 500 mL of enteral formula. If your patient uses less than 500 mL of formula in a feeding, RELiZORB must be disposed of after use. For enteral formula volumes greater than 500 mL and up to 1000 mL two RELiZORB cartridges can be connected together in a tandem configuration. Learn more about tandem RELiZORB here.
Can medicines be added when using RELiZORB?
If medications need to be added to the tube feeding line, they must be added to the line after RELiZORB. Medicines or saline flushes may be added to the side port of a Y-Connector extension set located between RELiZORB and the patient.
DO NOT place medicines in the enteral tube feeding bag or anywhere else before the RELiZORB cartridge. Passing medicines through RELiZORB may change how the medicine works or how RELiZORB breaks down fats. If you accidentally add medicines or flush solutions before RELiZORB, then the RELiZORB and all tubing and formula must be thrown away. You may restart feeding using a new RELiZORB and feeding set.
Can RELiZORB be used more than once?
No. Do not reuse RELiZORB. Each RELiZORB cartridge should only be used once. At the end of the feeding, throw away the RELiZORB cartridge. RELiZORB may not break down fats properly if it is reused.
How many RELiZORB cartridges can be used in a day by an individual patient?
Do not use more than two (2) RELiZORB cartridges in a day (24-hour period). You can use two RELiZORB cartridges in a tandem configuration, one right after the other, or space out the timing of their use.
Learn more in the RELiZORB Patient Guide.
Is RELiZORB covered by health insurance?
A RELiZORB Support Services Program Coordinator will work with your patient’s insurance provider to help determine whether RELiZORB is covered by your patient’s health insurance.
What if my patient’s insurance provider does not cover RELiZORB?
If your patient’s insurance plan has denied coverage for RELiZORB, you can encourage your patient to reach out to a RELiZORB Support Services Program Coordinator at 1-844-632-9271. For healthcare professionals, a Clinical Documentation Checklist, Peer to Peer Preparation Guide, and Letter of Medical Necessity Templates are available.
How will your patient get RELiZORB?
Once RELiZORB is prescribed, and the Patient Enrollment Form is completed, your patient will be contacted by a RELiZORB Support Services Program Coordinator to get all the information necessary to get them started on RELiZORB and to make sure they receive shipments as expected. If you or your patient have any questions, call RELiZORB Support Services at 1-844-632-9271.
How does my patient refill their RELiZORB prescription?
To refill their RELiZORB prescription, please have your patient call their RELiZORB Support Services Program Coordinator at 1-844-632-9271 and they will provide them with the contact information for a pharmacy that can dispense the product. They can also contact the pharmacy directly if they remember which pharmacy filled their first prescription.
What if my patient can’t afford the co-pay for RELiZORB?
For eligible patients with commercial health insurance, the RELiZORB Out-of-Pocket Assistance Program assists with out-of-pocket expenses, which can include co-pays, coinsurance, or deductibles.
Enrollment in the program is subject to confirmation of eligibility. RELiZORB Support Services will review your patient’s commercial health insurance benefits, and if they are eligible, they will be enrolled in the program.
How do I reach my RELiZORB Support Services Program Coordinator?
Call RELiZORB Support Services at 1-844-632-9271.
What if I have questions about RELiZORB?
RELiZORB Support Services can help with information and resources that can help address questions you may have. Call 1-844-632-9271.
Does RELiZORB have an HCPCS billing code?
Effective January 1, 2019, RELiZORB has a permanent, separately billable Medicare billing code (B4105). In addition, RELiZORB was assigned the PE04 (Enteral Equipment and/or Supplies) Product and Service Code, which may be relevant for certain patients under the July 11, 1984, Medicare National Coverage Determination for Enteral and Parenteral Nutritional Therapy (180.2).
Learn more on the RELiZORB Support Services page.
- Freedman S, Orenstein D, Black P, et al. Increased fat absorption from enteral formula through an in-line digestive cartridge in patients with cystic fibrosis. J Pediatr Gastroenterol Nutr. 2017;65(1):97-101.
- Stevens J, Wyatt C, Brown P, Patel D, Grujic D, Freedman SD. Absorption and Safety with Sustained Use of RELiZORB Evaluation (ASSURE) study in patients with cystic fibrosis receiving enteral feeding. J Pediatr Gastroenterol Nutr. 2018;Oct;67(4):527-532.